Western University BiologyWestern Science

Shiva Singh, PhD

Molecular Genetics of Complex Diseases and Phenotype


Shiva Singh Position:
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Professor (Distinguished University Professor)
Western Science Center 307
(519) 661-3135
519 661-3935
ssingh@uwo.ca
http://www.uwo.ca/biology/faculty/singh/
Our research program on genetic variation including human molecular genetics deals with genetic and epigenetic factors associated with complex diseases and phenotypes with a focus on neurogenomics. It using whole genome based methods (microarrays; expressed, SNPs and methylation specific oligonucleotide microarrays and complete genome sequences) in studies on Schizophrenia, Alcoholism, Fetal Alcohol Syndrome and Cancers. They involve human families including monozygotic twins discordant for the disease and mouse as the genetic animal model. The results obtained have offered a novel insight, particularly the importance of epigenetics and gene regulation in the dissection of behaviors. This novelty is recognized by the genetics community including granting agencies (NSERC, NAMI (NIH), CIHR, ATCG, OMHF, SSO, etc.) who have funded this research fully and adequately for over 35 years.

Teaching

Most Recent Ph.D. Graduates

Katarzyna Mantha Haroon Sheikh Christina Castellani Morgan Kleiber Raihan Uddin Ben Laufer

Most Recent Publications

  1. Chater-Diehl, EJ, Benjamin I. Laufer, Christina A. Castellani, Bonnie L. Alberry, Shiva M. Singh (2016). Alteration of gene expression, DNA methylation, and histone methylation in free radicalscavenging networks in adult mouse hippocampus following fetal alcohol exposure. PLoS One. PMID: 27136348
  2. Alberry B. and SM Singh (2016). Developmental and behavioral consequences of early life maternal separation stress in a mouse model of FASD. Behavioural Brain Research 308:
  3. Castellani, C., M G Melka, JL Gui, R O’Reilly and SM Singh (2015). Integration of DNA sequence and DNA methylation changes in two MZ twin pairs discordant for Schizophrenia. Schizophrenia Research 169:433-440.
  4. Castellani, CA., Melka*, MG., Gui*, JL., Gallo*, AJ., O’Reilly, RL., Singh, SM. (2016). Genomes of monozygotic twins discordant for schizophrenia delineate de novo features of twin differences and disease threshold. Translational Psychiatry (Submitted).
  5. Castellani, C., Melka, M., Gui JL, O'Reilly, R and SM Singh. (2015). Integration of DNA Sequence and DNA Methylation Changes in Two Monozygotic Twin Pairs Discordant for Schizophrenia. Schizophrenia Research 169:433-440.
  6. Laufer, B and S.M. Singh. (2015). Strategies of precision modulation of gene expression by epigenome editing: An Overview. Epigenetics and chromatin. PMID: 26388942
  7. Laufer, B., Kapalanga, J., Castellani*, C.A., Diehl*, E.J., Yan, L., and Singh, S.M.(2015). Associative DNA Methylation Changes in Children with FASD. Epigenomics:1-16.
  8. Ouellette, SJ, E Russell, KR Kryski, H Sheikh, S Singh, G Koren. (2015). Hair cortisol concentrations in higher- and lower-stress mother-daughter dyads: A pilot study of associations and moderators. Developmental psychobiology. PMID: 25820649
  9. Melkaye G. Melka*, Christina A. Castellani*, Richard O’Reilly and Shiva M. Singh. (2015). Insights into the origin of DNA methylation differences between monozygotic twins discordant for Schizophrenia. Journal of Molecular Psychiatry. PMID: 26137221
  10. Ben Laufer, Shiva M. Singh. (2015). Strategies for precision modulation of gene expression by epigenome editing: an overview. Epigenetics and Chromatin 8: 34.
  11. Castellani, Benjamin I Laufer, Melkaye G Melka, Eric J Diehl, Richard L O'Reilly and Shiva M Singh. (2015). DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. BMC Med Genomics 8:17.
  12. Castellani, Melka, Diehl, Laufer, O'Reilly, Singh. (2015). DNA methylation in psychosis: insights into aetiology and treatment. Epigenomics 7:67-74.
  13. Melka MG, Rajakumar N, O'Reilly R, Singh SM. (2015). Olanzapine induced DNA methylation in the hippocampus and cerebellum in genes mapped to human chromosome 22q11 and implicated in schizophrenia. Psychiatric Genetics. PMID: 25415458

A more comprehensive list of publications from the Singh Lab can be seen on PubMed

Also Check out: Singh Lab Research projects on lab website