David Smith, PhD
Genome evolution and genetic diversity of microbial eukaryotes
We study genome architecture, genetic diversity, and the evolutionary forces that fashion genes and chromosomes. We’re interested in how nonadaptive processes shape genomes, including their nucleotide composition, compactness, conformation, chromosome number and telomeres. Much of our research employs protists (microbial eukaryotes). Protists have among the most diverse and eccentric genomes in the biological world, yet they are generally an untapped resource for studying genome evolution. We love weird genomes and trying to understand how they got that way.
Degrees and Institutions
- B.Sc. (Biology) Acadia University
- Ph.D. (Genetics and Evolution) Dalhousie University
- Biology 4200B - Genome Evolution
- Biology 4441F - Special Topics in Evolution
- Smith DR, Keeling PJ (2015) Mitochondrial and plastid genome architecture: reoccurring themes, but significant differences at the extremes. Proceedings of the National Academy of Sciences USA. In press.
- Smith DR (2015) Buying in to bioinformatics: an introduction to commercial sequence analysis software. Briefings in Bioinformatics. In press.
- Smith DR (2015) The commercialization and outsourcing of science: the future of academic research. EMBO reports. 16:14–6.
- Smith DR, Asmail SR (2014) Next-generation sequencing data suggest that certain nonphotosynthetic green plants have lost their plastid genomes. New Phytologist. 204:7–11.
- Smith DR, Lee RW (2014) A plastid without a genome: evidence from the nonphotosynthetic green alga Polytomella. Plant Physiology. 164:1812–1819